Prototype is kicking my ass all over town. I'm playing on PC. It's a great escape during a tough time in my life, and it's an incredible game all around. I love the way the guy you play--Alex Mercer--is more powerful than any character I've played in a game in the past several years.
Imagine the strength of the Hulk, the agility of Spider-Man, and the rage and anger of Wolverine in one neat package that can also absorb people and beasts and gain their memories and powers. Tearing through the streets and rooftops of Manhattan is fun enough; hijacking APCs and helicopters, destroying entire buildings in minutes, wiping out platoons of military with a few mouse clicks, and leaving a path of blood and destruction is all icing on the cake.
The Web of Intrigue system, in which Alex learns clues about his past (he starts the game as so many game characters do, with amnesia) and how he gained his Godlike power by absorbing certain individuals and plumbing their memories. It's a genius way to tell a story in a sandbox game. You can play this game at your pace and there's plenty to do in a city overrun by a virus (that might be related to your powers) that's turning people into monsters, with the military trying to "contain" the outbreak basically by killing every that moves. You can advance the plot with story missions or partake in a number of side activities, a la Saint's Row.
I'm probably about halfway through Prototype and I'm digging every second of it. This is Game of the Year material, easilyMy only gripe is that the controls are way complicated, but you get used to it. My advice is to ignore the few negative reviews (some people just don't get it) and, if you're into sandbox games with superpowered antiheroes, grab a copy and dig in. Enjoy.